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In addition, the main transcription factor of iron metabolism, iron response element binding protein 2 (IREB2), could enhance the FTL and FTH1 expression and decrease ferrous ion concentrations, thereby inhibiting erastin-induced ferroptosis ( Ferroptosis could be induced by directly supplementing the cell's active iron pool to establish an iron overload state
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Since glutathione plays such a pivotal role in the body, factors that may contribute to its depletionβincluding certain lifestyle habits, environmental exposures, and pharmaceutical useβare of increasing interest to researchers and health-conscious individuals alike